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Многие пациенты, в том числе с протезированными клапанами сердца, принимают антикоагулянты непрямого действия, такие как варфарин, синкумар, фенилин для лечения и профилактики тромбозов и эмболии кровеносных сосудов. В такой антикоагуляционной терапии огромное значение отводится мониторингу МНО, необходимому для подбора индивидуальной дозировки принимаемого антикоагулянта. При этом целевой диапазон МНО и частота его измерения сугубо индивидуальны и определяются лечащим врачом.

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